The Health Dangers of Roundup (glyphosate) Herbicide. Jeffrey Smith & Stephanie Seneff

Glyphosate’s Suppression of Cytochrome P450 Enzymes

Full study here: Gly, Modern disease,Samsel-Seneff pdf

Abstract:

Glyphosate, the active ingredient in Roundup®, is the most popular herbicide used worldwide. The industry asserts it is minimally toxic to humans, but here we argue otherwise. Residues are found in the main foods of the Western diet, comprised primarily of sugar, corn, soy and wheat. Glyphosate’s inhibition of cytochrome P450 (CYP) enzymes is an overlooked component of its toxicity to mammals. CYP enzymes play crucial roles in biology, one of which is to detoxify xenobiotics. Thus, glyphosate enhances the damaging effects of other food borne chemical residues and environmental toxins. Negative impact on the body is insidious and manifests slowly over time as inflammation damages cellular systems throughout the body. Here, we show how interference with CYP enzymes acts synergistically with disruption of the biosynthesis of aromatic amino acids by gut bacteria, as well as impairment in serum sulfate transport. Consequences are most of the diseases and conditions associated with a Western diet, which include gastrointestinal disorders, obesity, diabetes, heart disease, depression, autism, infertility, cancer and Alzheimer’s disease. We explain the documented effects of glyphosate and its ability to induce disease, and we show that glyphosate is the “textbook example” of exogenous semiotic entropy: the disruption of homeostasis by environmental toxins.

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See comment in PubMed Commons below

Interdiscip Toxicol. 2013 Dec;6(4):159-84. doi: 10.2478/intox-2013-0026.

Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance.

Samsel A¹, Seneff S².

Author information

Abstract

Celiac disease, and, more generally, gluten intolerance, is a growing problem worldwide, but especially in North America and Europe, where an estimated 5% of the population now suffers from it. Symptoms include nausea, diarrhea, skin rashes, macrocytic anemia and depression. It is a multifactorial disease associated with numerous nutritional deficiencies as well as reproductive issues and increased risk to thyroid disease, kidney failure and cancer. Here, we propose that glyphosate, the active ingredient in the herbicide, Roundup(®), is the most important causal factor in this epidemic. Fish exposed to glyphosate develop digestive problems that are reminiscent of celiac disease. Celiac disease is associated with imbalances in gut bacteria that can be fully explained by the known effects of glyphosate on gut bacteria. Characteristics of celiac disease point to impairment in many cytochrome P450 enzymes, which are involved with detoxifying environmental toxins, activating vitamin D3, catabolizing vitamin A, and maintaining bile acid production and sulfate supplies to the gut. Glyphosate is known to inhibit cytochrome P450 enzymes. Deficiencies in iron, cobalt, molybdenum, copper and other rare metals associated with celiac disease can be attributed to glyphosate's strong ability to chelate these elements. Deficiencies in tryptophan, tyrosine, methionine and selenomethionine associated with celiac disease match glyphosate's known depletion of these amino acids. Celiac disease patients have an increased risk to non-Hodgkin's lymphoma, which has also been implicated in glyphosate exposure. Reproductive issues associated with celiac disease, such as infertility, miscarriages, and birth defects, can also be explained by glyphosate. Glyphosate residues in wheat and other crops are likely increasing recently due to the growing practice of crop desiccation just prior to the harvest. We argue that the practice of "ripening" sugar cane with glyphosate may explain the recent surge in kidney failure among agricultural workers in Central America. We conclude with a plea to governments to reconsider policies regarding the safety of glyphosate residues in foods.

KEYWORDS:

celiac disease; cytochrome P450; deficiency; food; gluten; glyphosate

PMID:: 24678255
PMCID:: PMC3945755
DOI:: 10.2478/intox-2013-0026

Free PMC Article

Dr. Stefanie Seneff on Sulfates and Aluminum in the Brain

Neurological disorders, autoimmune diseases—they seem to be everywhere these days. Scientists writing in Neurology in 2007 estimated that the burden of neurologic illness affects “many millions of people in the United States.”¹

Autoimmune illness, too, is at epidemic proportions—nearly 24 million Americans as of 2012.² These trends are disturbing enough in their own right, but even more disturbing is the general scientific apathy about why the surge in these diseases is occurring.

Why do the causes of these alarming epidemics remain “underrecognized and underaddressed?”³

Stephanie Seneff is one of the all-too-rare scientists who is trying to ask the questions and connect the dots. Dr. Seneff⁴ is a senior research scientist at the MIT Computer Science and Artificial Intelligence Laboratory with an illustrious career and lengthy publication record.

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GP Question:

How can we be sure that certified organic, non-GMO products are not grown on soil composed of Biosolids? Are the certifying agencies even cognizant of biosolids and their toxic neurological effects?

Dr. David Lewis:

Good question, Gerald. The underlying problem is that the U.S. EPA declared that, once biosolids is composted, it's no longer "sewage sludge." That potentially allows treated sewage sludge to circumvent USDA prohibitions on use of sewage sludge to grow USDA-certified organic foods. At this point in time, we don't really know whether organic farms are taking advantage of this loophole. If so, that's a big problem. Recalcitrant chemical pollutants, including powerful mutagens, carcinogens and endocrine disruptors in sewage sludges are not effectively reduced in concentration, or destroyed, by composting.

LINK TO USDA NATIONAL ORGANIC FARMING PROGRAM

USDA NATIONAL ORGANIC PROGRAM STAFF DIRECTORY PDF

Under Pressure, Whole Foods Agrees to Stop Selling Produce Grown in Sewage Sludge

Submitted by Rebekah Wilce on January 15, 2014 - 7:21am

The Center for Media and Democracy (CMD) broke the story that the $12.9 billion-a-year natural and organic foods retailer Whole Foods Market had a policy of "don't ask, don't tell" when it comes to "conventional" -- or non-organic -- produce being grown in fields spread with sewage sludge, euphemistically called "biosolids." Certified organic produce cannot be fertilized with sewage sludge, which is the industrial and hospital waste and human excrement flushed down the drains and later -- in some cases -- spread on some crops.

Since this story broke, nearly 8,000 activists and PRWatch readers have sent emails to Whole Foods executives asking the company to require its suppliers to disclose this information and to label produce grown in sewage sludge so that customers can make informed decisions.

Mario Ciasulli, a semi-retired engineer and home cook living in North Carolina whom CMD profiled in December 2012, blew the whistle on Whole Foods' don't-ask, don't-tell policy. As soon as he found out that shopping at Whole Foods was no protection against this potential contamination unless he could afford to buy only certified organic produce, he worked extensively to engage Whole Foods on this issue. He has insisted that management address his concerns about potential contamination of non-organic produce, price barriers to organic produce for those who are concerned, and the difficulty of finding out what non-organic produce may have been grown in soil fertilized with sewage sludge without labeling and accountability.

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The Health Dangers of Roundup (glyphosate) Herbicide. Jeffrey Smith & Stephanie Seneff

Glyphosate’s Suppression of Cytochrome P450 Enzymes

Abstract:

Cytochrome P450

Genetic Roulette: The Gamble Of Our Lives

Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance.

Author information

Abstract

KEYWORDS:

Dr. Stefanie Seneff on Sulfates and Aluminum in the Brain

Genetically Modified Foods