Uploaded on Nov 4, 2011
Dr. Christopher Exley- The Systemic Toxicity of Aluminium Adjuvants.
Dr. Christopher Exley is the Reader in Bioinorganic Chemistry at The Birchall Centre, Keele University in Staffordshire and Honorary Professor at the UHI Millennium Institute. Exley is a biologist (University of Stirling) with a PhD in the ecotoxicology of aluminium (University of Stirling). His research career (1984-present) has focused upon an intriguing paradox; ‘how the third most abundant element of the Earth’s crust (aluminium) is non-essential and largely inimical to life’. Investigating this mystery has required research in myriad fields from the basic inorganic chemistry of the reaction of aluminium and silicon to the potentially complex biological availability of aluminium in humans. Exley is also fascinated by the element silicon in relation to living things which, as the second most abundant element of the Earth’s crust, is also almost devoid of biological function. One possible function of silicon is to keep aluminium out of biology (biota) and this area of study forms a large part of Exley’s research.
Christopher A. Shaw, Ph.D, Professor
Dr. Romain Gherardi
Nanosized particles injected into muscle slowly disseminate within phagocytes
Dr. Romain K. Gherardi is a French specialist of neuromuscular diseases. He graduated in clinical Neurology and Pathology, and has been a Professor since 1990. He is working at the Henri Mondor hospital, the second largest hospital of Assistance Publique- Hôpitaux de Paris, located in Créteil and depending of Paris-Est University. He heads the department of Histology that includes both Neuropathologic and Clinical activities in the setting of a Neuromuscular disease reference center. He also heads an experimental research team entitled ‘Cellular interactions in the Neuromuscular system” (INSERM U955-E10) at the Institut Mondor de Recherche Biomédicale (IMRB).
From 1983 to 2010, Gherardi has published 290 articles indexed in PubMed, and monitored 14 PhD and 10 MSc students on the topic of biology, pathology and clinics of the nervous and muscular system. He previously studied several immuno-inflammatory and toxic neuromuscular disorders (almitrine neuropathy, zidovudine myopathy, statin myopathy, etc). He is currently working on innate immune reactions to myoinjury, biodistribution of nanoparticles, and pathophysiology of ‘macrophagic myofasciitis” a neurologic disease linked to the long term persistence of Alum adjuvant in monocyte/macrophage lineage cells.
Gherardi is reviewer for Science, N Engl J Med, Lancet, Ann Neurol, Arthritis Rheum, Stem Cells, Stem Cell Dev, Neuromuscular Disord, Muscle Nerve, etc. On the topic of macrophagic myofasciitis, he was an invited speaker by the Centers for Disease Control, WHO Geneva, French government agencies, the French Parliament committee on Gulf War syndrome, and a variety of national and international scientific and medical societies.
Vaccine Safety Conference Session 13 – Dr. Yehuda Shoenfeld, MD, FRCP
Uploaded on Dec 28, 2011
ASIA – Autoimmune (Auto-Inflammatory) Syndrome Induced by Adjuvant: A New Syndrome to be Defined
Dr. Yehuda Shoenfeld is the head of the Department of Medicine at the Tel Aviv University since 1984 (age 36). Has founded and is heading the Center for Autoimmune Diseases since 1985 – at the largest hospital in Israel- the Sheba Medical Center, which is affiliated to the Sackler Faculty of Medicine in the Tel-Aviv University.
Shoenfeld is the Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases in Tel-Aviv University. His clinical and scientific work focuses on Autoimmune Rheumatic Diseases. He has published over 1600 papers in journals such as New Eng J Med, Nature, Lancet, Proc Nat Acad Scie, J Clin Invest, J Immunol, Blood, FASEB, J Exp Med, Circulation, Cancer and others. His articles have had over 20,000 citations until 2009. He has authored and edited 25 books, some of which became cornerstones in science and clinical practice, such as “The Mosaic of Autoimmunity”, “Infections and Autoimmunity”, the textbook “Autoantibodies” and “Diagnostic Criteria of Autoimmune Diseases”, all of which were published by Elsevier and sold by thousands.
He is on the editorial board of 43 journals in the field of Rheumatology, and Autoimmunity and is the founder and the editor of the IMAJ (Israel Medical Association Journal) the representative journal of Science and Medicine in the English language in Israel. Shoenfeld is also the founder and Editor of the “Autoimmunity Reviews” (Elsevier) (Impact factor 6.2). He has written over three hundred chapters in different books. For the last 20 years Shoenfeld has been the Editor of “Harefuah” — The Israel journal in medicine (Hebrew) and edited the Israel Medical Encyclopedia (10 volumes, 5000 items). He has organized over 20 International Congresses in Autoimmunity.
Recently he has opened the new Zabludowicz Center for Autoimmune Diseases in The Chaim Sheba medical Center.